Friday, February 24, 2017

In Situ Microbial Fermentation Analysis and Mammalian Cell Culture Analysis - for R&D and Mass Production

Biopharmaceutical production processes, including microbial fermentation and mammalian cell culture vary greatly with organisms behaving differently and metabolizing at varying rates. With in-process measurements you can monitor the key parameters and optimize the fermentation or cell culture processes. Using a bioprocess analyzer allows for rapid analysis of many different properties with one quick measurement.

Both Fermentation and Cell Culture processes in a single, closed vessel can benefit greatly from in-process or in situ chemical analysis. Whether you are working with small laboratory scale reactors or large scale production equipment, Near Infrared (NIR) analysis can make your processes more efficient and optimized. NIR provides useful analysis for R&D, Scale-up, Process Development and full-scale production. Large-scale fermenters and bioreactors can hold as many as 250,000 gallons of raw material, which may be in process for hours or several weeks. An NIR analyzer can monitor both the start up media and emerging product on-line, despite the thick, soupy nature of the material.

Additionally you can get online measurements of Glucose, Glutamate, Acetate, Lactate, Ammonia,
Cell Density, Product Titer/Protein with NIR analyzers. These properties can be measured In-Situ or in the lab. If you have many fermentors/reaction vessels,  optical multiplexers will allow one analyzer to monitor up to 20 measurement points, sending all the valuable data to your process control system automatically.

In mass production the electrical power savings alone can provide payback for an NIR analyzer within a few months. Added product yield from improved process control also generates enormous payback, as well as reducing the occurrences of lost batches.

For more information visit Flow-Tech here or call 410-666-3200 in Maryland and 804-752-3450 in Virginia.